UNITYTM covers carrier screening for all ACOG-recommended conditions
UNITYTM provides carrier screening for pregnant and non-pregnant samples from female and male patients. Reflex single-gene NIPT2 is available for ACOG-recommended disorders:
Cystic fibrosis (CFTR)
Spinal muscular atrophy (SMN1)
Sickle cell disease (HBB)
Alpha and beta-thalassemia (HBA1, HBA2, HBB)
In addition, expanded carrier
screening (43 genes, NGS panel)
is available for individuals of
Ashkenazi Jewish, French Canadian,
and Cajun descent. 2
In addition to existing guidance recommending universal screening for cystic fibrosis, all women should also be offered screening for spinal muscular atrophy (SMA). ACOG committee opinion 691, issued March 2017
UNITYTM performs carrier testing on the pregnant mother using next-generation sequencing followed by confirmatory Sanger sequencing. For copy number variations, especially in SMA and alpha-thalassemia, digital MLPA is performed. If the result is positive, cell-free DNA is analyzed for the number of molecules with mutations and those without mutations by transforming next- generation sequencing data to digital molecular counts. BillionToOne is the only NIPT provider for
detecting recessive conditions without requiring paternal DNA.
UNITYTM IN YOUR PRACTICE
Online order via EMR system available.
Collect Blood Sample
Collect just one tube of maternal blood.
We perform carrier screening and reflex
single-gene NIPT from a single blood sample.1
Ship the sample using pre-labeled kit.
Receive Results in 2 Weeks
Results sent to physician within 2 weeks. Access test results online.
Access Complimentary Genetic Counseling
Complimentary genetic counseling sessions are available for all patients.
Connect With Us
UNITYTM is available to limited number of clinics through Early Access Program.
Contact us to learn more.
Small number of cases require a secondary draw, which
include when the gestational age is under 10 weeks, the fetal
fraction is less than 5%, or when the test is inconclusive