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UNITY allows pregnant patients to have access to safe, accurate, and accessible prenatal screening for recessive conditions and aneuploidies.
UNITY allows pregnant patients to have access to safe, accurate, and accessible prenatal screening for recessive conditions and aneuploidies.
Streamline management of alloimmunized patients with non-invasive screening for fetal antigens
While rare, Hemolytic Disease of the Fetus and Newborn (HDFN) can be deadly. Screening for C, c, D, E, Duffy (Fya), and Kell (K) antigens can now be added to any UNITY aneuploidy order.
If patient is alloimmunized for C, c, D, E, Duffy (Fya), or Kell (K):
2. ACOG Practice Bulletin No. 192: Management of Alloimmunization During Pregnancy. Obstet Gynecol. 2018 Mar;131(3):e82-e90. doi: 10.1097/AOG.0000000000002528. PMID: 29470342.48(5):941-52. doi: 10.1111/j.1537- 2995.2007.01625.x. Epub 2008 Feb 1. PMID: 18248570. 3. Koelewijn JM, et al. Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in the Netherlands. Transfusion. 2008 May; 48(5):941-52. doi: 10.1111/j.1537-2995.2007.01625.x. Epub 2008 Feb 1. PMID: 18248570.
NEW! For alloimmunized patients, UNITY now screens for the presence of red blood cell fetal antigens non-invasively and early in pregnancy
UNITY™ sgNIPT has shown > 98.5% sensitivity and >99% specificity in a peer reviewed publication.
It has also shown 100% concordance with newborn screen results in NIH-sponsored clinical study with Baylor College of Medicine and a study with University of Alabama Birmingham.
Single-Molecule Accuracy Powered by QCT™
Using QCT™ molecular counting technology, UNITY™ is able to differentiate homozygous affected fetus (colored bars) from carrier fetus (gray bar). In addition, UNITY™ performs a paternal allele assay to detect a fetus at-risk to be compound heterozygous for CFTR or HBB at >98% detection rate.
Exemplary Readout. Chromosome 21 Ratio: euploid vs trisomy 21
UNITY™ sgNIPT and Aneuploidy + RhD NIPT use synthetic molecules and computational decoding in the bioinformatics stage to reduce the assay amplification noise down to the theoretical limit. Thanks to these proprietary technologies, UNITY™ can uniquely offer reflex sgNIPT and Rh NIPT solutions.
NEW! For alloimmunized patients, UNITY now screens for the presence of RBC fetal antigens associated with severe HDFN
While rare, Hemolytic Disease of the Fetus and Newborn (HDFN) can be deadly. Screening for C, c, D, E, Duffy (Fya), and Kell (K) antigens can now be added to any UNITY aneuploidy order.
